2-[(2-amino-thiazol-4-yl)-carboxy-methyleneaminoxy]-2-methyl-propionic acid (intermediate of aztreonam)
2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid
CAS: 80542-76-3
Molecular Formula: C22H21N3O5S
2-[(2-amino-thiazol-4-yl)-carboxy-methyleneaminoxy]-2-methyl-propionic acid (intermediate of aztreonam) - Names and Identifiers
2-[(2-amino-thiazol-4-yl)-carboxy-methyleneaminoxy]-2-methyl-propionic acid (intermediate of aztreonam) - Physico-chemical Properties
| Molecular Formula | C22H21N3O5S |
| Molar Mass | 439.48 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boling Point | 627.2±65.0 °C(Predicted) |
| pKa | 2.55±0.10(Predicted) |
| Refractive Index | 1.658 |
2-[(2-amino-thiazol-4-yl)-carboxy-methyleneaminoxy]-2-methyl-propionic acid (intermediate of aztreonam) - Introduction
2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid, also known as ACMA(2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid).
Nature:
ACMA is a white to pale yellow crystalline solid with a chemical formula C10H12N4O5S and a relative molecular mass of 292.299g/mol. It has high solubility in water.
Use:
ACMA has some important applications in medicine and chemistry. It is mainly used as an intermediate and plays a key role in drug research and synthesis. ACMA can also be used for nucleophilic substitution reactions, coupling reactions and removal of protecting groups in organic synthesis. In addition, it can also be used as a precursor of ultrasound contrast agents and anti-tumor drugs.
Preparation Method:
There are various methods for preparing ACMA. A common synthetic method is the reaction of 2-aminothiazole-4-carbaldehyde with a hydroxylamine salt to give 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid.
Safety Information:
The safety of ACMA varies depending on the specific environment and use. When handling and storing ACMA, appropriate protective measures should be taken, such as wearing protective gloves and glasses, and maintaining good ventilation conditions. When using ACMA, the relevant safety procedures and personal protective measures should be strictly observed. If you ingest or come into contact with ACMA, you should seek medical help immediately.
Nature:
ACMA is a white to pale yellow crystalline solid with a chemical formula C10H12N4O5S and a relative molecular mass of 292.299g/mol. It has high solubility in water.
Use:
ACMA has some important applications in medicine and chemistry. It is mainly used as an intermediate and plays a key role in drug research and synthesis. ACMA can also be used for nucleophilic substitution reactions, coupling reactions and removal of protecting groups in organic synthesis. In addition, it can also be used as a precursor of ultrasound contrast agents and anti-tumor drugs.
Preparation Method:
There are various methods for preparing ACMA. A common synthetic method is the reaction of 2-aminothiazole-4-carbaldehyde with a hydroxylamine salt to give 2-[(2-Aminothiazol-4-yl)carboxymethyleneaminooxy]-2-methylpropionic acid.
Safety Information:
The safety of ACMA varies depending on the specific environment and use. When handling and storing ACMA, appropriate protective measures should be taken, such as wearing protective gloves and glasses, and maintaining good ventilation conditions. When using ACMA, the relevant safety procedures and personal protective measures should be strictly observed. If you ingest or come into contact with ACMA, you should seek medical help immediately.
Last Update：2024-04-09 15:18:00
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2-[(2-amino-thiazol-4-yl)-carboxy-methyleneaminoxy]-2-methyl-propionic acid (intermediate of aztreonam)
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Ruphos Pd G4
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